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Stephen A. Cannistra, MD, FASCO, was among the first scientists to define the mechanisms by which ovarian cancer cells spread throughout the peritoneal cavity. His work further defined the role of apoptosis in mediating chemotherapy-induced killing of ovarian cancer cells, as well as the possibility of using gene expression arrays to predict chemotherapy responsiveness in this disease. In the clinic, he was one of the first to show that the anti-angiogenic agent bevacizumab was active in patients with recurrent disease, paving the way for using this drug in the first-line setting.